Key result
Cardiac Na+/Ca2+ exchange is modulated by diverse regulatory elements, with S100A1 identified as a presumably novel regulator, while the role of cyclic nucleotides and protein kinases remains debated.
This review highlights the complex regulatory mechanisms of the cardiac Na+/Ca2+ exchanger in normal and failing hearts, pointing to S100A1 as a novel regulator.
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Complex NCX regulation leaves S100A1 as a hypothesis-generating target in HF; no practice change indicated.
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Reppel et al. (2007) conducted a review in Normal and failing heart. Cardiac Na+/Ca2+ exchange is modulated by diverse regulatory elements, with S100A1 identified as a presumably novel regulator, while the role of cyclic nucleotides and protein kinases remains debated.
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