Population
Cardiac myocytes (rat), transgenic mice, and NCX1 knockout mice
Comparison
Alterations in NCX1 activity and deletion of… vs Wild-type NCX1 exchangers
Design
Review
Authors
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NCX1 modulation unlikely to alter ECC substantially; leaves open dominant roles of Na+ gradient and SERCA in human Ca2+ handling.
Recent studies reveal that NCX1 gating reactions operate in the physiological range of Ca2+ changes and that large variations in NCX1 activity have surprisingly modest effects on the cardiac excitation-contraction cycle.
Donald W. Hilgemann (2004) studied this question.
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