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This review examines transmembrane auxiliary subunits of voltage-dependent ion channels, highlighting their structure and functions.
Auxiliary subunits of voltage-dependent ion channels can be subdivided into two classes. One class consists of the entirely cytoplasmic intracellular subunits, which have no transmembrane domains such as the β subunit of the voltage-dependent Ca2+ channel and the β subunit of the voltage-dependent K+ channel. The other class of auxiliary subunits contains at least one transmembrane domain and an extracellular glycosylated region. This review will concentrate on the transmembrane auxiliary subunits.
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Gurnett et al. (1996) studied this question.
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