Key result
Development of new carotid plaques occurred more frequently in women with baseline intimal-medial thickening than in those with normal carotid arteries (14.4% vs 7.2%, P<.053).
Why the study?
What are the risk factors for the development and regression of early carotid atherosclerotic lesions in healthy middle-aged women?
Population
308 apparently healthy women aged 45 to 55 years
Design
Cohort
Follow-up
2 years
Authors
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Baseline carotid thickening identifies higher-risk women; observational data leave open ultrasonography's role in guiding prevention.
Cohort (n=308)
What are the risk factors for the development and regression of early carotid atherosclerotic lesions in healthy middle-aged women?
Absolute Event Rate: 14.4% vs 7.2%
p-value: p=<.053
Smoking, systolic blood pressure, and apolipoprotein B are independent predictors of early carotid plaque development in healthy middle-aged women, supporting the use of B-mode ultrasonography for monitoring early atherosclerosis.
Bonithon‐Kopp et al. (1993) conducted a cohort in Early carotid atherosclerosis (n=308). Intimal-medial thickening vs. Normal carotid arteries was evaluated on Development of new atheromatous plaques (p=<.053). Development of new carotid plaques occurred more frequently in women with baseline intimal-medial thickening than in those with normal carotid arteries (14.4% vs 7.2%, P<.053).
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