Key result
Cardiac antiarrhythmic drugs modify arrhythmias through specific mechanisms, often attributable to their use-dependent interactions with specific cellular channels.
Understanding the cellular mechanisms and channel-specific interactions of antiarrhythmic drugs is crucial for explaining their clinical effects and guiding the development of new therapies.
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Supports mechanism-guided antiarrhythmic selection; leaves open need for prospective validation in clinical outcomes.
In the preceding pages we have considered a number of mechanisms whereby drugs may modify arrhythmias and we also have demonstrated that certain types of action are specific to individual drugs. In addition, through the description of the use-dependence of drug effects, we have shown that the specificity of a drug's action often is attributable to its interactions with specific channels. As we learn more about the specificity of individual drug effects we should be better able not only to understand the actions of presently available drugs, but also to discover compounds that promise to be of use in the future.
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Binah et al. (1984) conducted a review in Arrhythmias. Cardiac antiarrhythmic drugs was evaluated. Cardiac antiarrhythmic drugs modify arrhythmias through specific mechanisms, often attributable to their use-dependent interactions with specific cellular channels.
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