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A novel micelle platform consisting of amphiphilic DNA block copolymers is introduced for chemotherapeutic drug delivery, allowing combinatorial testing of the drug carrier system. Oligodeoxynucleotide modified targeting units are “clicked” into the micelle corona by hybridization, allowing perfect control of surface functionalities of the nanoparticle system. Cancer cells are efficiently killed when targeting units and chemotherapeutic act together within the DNA block copolymer aggregates. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂089/2008/c0866ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Alemdaroglu et al. (Wed,) studied this question.
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