Can HbA1c predict quality of life in children with type 1 diabetes mellitus?

Abstract BackgroundThe aim of this study was to examine a possible association of HbA1c, quality of life (QoL), fitness, and electrophysiological parameters in children with type 1 diabetes mellitus (T1DM).MethodsThe study population (n = 34) consisted of patients with T1DM (n = 17) and an age- and BMI-matched healthy control group (n = 17). HbA1c was obtained from patients with T1DM at time of diagnosis (T0), at 6 months (T6), at 12 months (T12), and at time of study inclusion (Tstudy). QoL was determined with a standardized questionnaire (KINDL-R). All children completed a 6-minute walk test (6MWT) to evaluate their fitness level. Electrodiagnostic studies established upper and lower limb motor and sensory nerve conduction velocities (NCV).ResultsHigher HbA1c (Tstudy) was associated with lower QoL showing in the subscales self-esteem, friends and school. Higher HbA1c (T6) and (T12) was associated with lower QoL in the subscale self-esteem. Based on various subscales, perceived problem areas differed significantly between children and their parents. No differences in fitness level and NCV were found between patients and controls except for a significantly slower median motor NCV in patients. HbA1c was not associated with NCVs at this early stage of disease.ConclusionsGood metabolic control reflected by adequate HbA1c values seems to be important for a good QoL in children with T1DM. Early HbA1c analysis serves as predictor for QoL during follow-up.Trial registration: Retrospectively registered