Key result
Intravenous diltiazem at 0.2 mg/kg provided superior attenuation of the hemodynamic stress response during laryngoscopy and intubation compared to lignocaine 1.5 mg/kg, significantly lowering the rate pressure product.
Why the study?
Does intravenous diltiazem reduce the hemodynamic pressor response to laryngoscopy and endotracheal intubation compared to lignocaine in normotensive adults undergoing elective surgery?
RCT (n=90)
Double-blind
Randomly allocated
No
Does intravenous diltiazem reduce the hemodynamic pressor response to laryngoscopy and endotracheal intubation compared to lignocaine in normotensive adults undergoing elective surgery?
Intravenous diltiazem at 0.2 mg/kg provides superior attenuation of the hemodynamic stress response during laryngoscopy and endotracheal intubation compared to diltiazem 0.1 mg/kg and lignocaine 1.5 mg/kg.
May warrant preferring diltiazem 0.2 mg/kg over lignocaine to blunt intubation response; reinforces calcium channel blocker utility in perioperative hemodynamics.
Tachycardia and systolic hypertension are considered the usual circulatory responses to laryngoscopy and tracheal intubation, occurring by virtue of sympathetic response, 1,2 accompanied by catecholamine activity. Hence, suppression of this response is beneficial.
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Parkar et al. (2018) conducted an RCT in Hemodynamic stress response during laryngoscopy and endotracheal intubation (n=90). Diltiazem vs. Lignocaine 1.5 mg/kg was evaluated on Rate pressure product at 1 minute post-intubation (p=0.000). Intravenous diltiazem at 0.2 mg/kg provided superior attenuation of the hemodynamic stress response during laryngoscopy and intubation compared to lignocaine 1.5 mg/kg, significantly lowering the rate pressure product.
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