Key result
Simulations using a mathematical model suggest that increased arterial stiffness in the upper body may explain both hypertension in treated patients and why diagnosis can be difficult.
Why the study?
Coarctation of the Aorta diagnosis can be difficult, treatments result in idiopathic sequelae including hypertension, and untreated patients develop worsening upper-body arterial stiffness.
Does increased arterial stiffness explain hypertension in treated patients and diagnostic difficulty in Coarctation of the Aorta?
Does increased arterial stiffness explain hypertension in treated patients and diagnostic difficulty in Coarctation of the Aorta?
A one-dimensional mathematical model suggests that increased upper body arterial stiffness may explain post-treatment hypertension and diagnostic challenges in Coarctation of the Aorta.
May inform stiffness assessment in post-repair CoA hypertension; hypothesis-generating and requires prospective patient validation.
Coarctation of the Aorta is a congenital narrowing of the aorta and diagnosis can be difficult. Treatments result in idiopathic sequelae including hypertension. Untreated patients are known to develop increased arterial stiffness in the upper body, which worsens with time. We present results from simulations with a one-dimensional mathematical model, about the effect of stiffness, stenting, surgery and coarctation severity on blood pressure, Pulsatility and Resistivity Index. One conclusion is that increased stiffness may explain both hypertension in treated patients and why diagnosis can be difficult.
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Pathirana et al. (2019) studied Coarctation of the Aorta. Simulated increased arterial stiffness, stenting, surgery, and coarctation severity was evaluated on Blood pressure, Pulsatility and Resistivity Index. Simulations using a mathematical model suggest that increased arterial stiffness in the upper body may explain both hypertension in treated patients and why diagnosis can be difficult.
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