Key result
Acute fenfluramine increased plasma 5-HT up to 24-fold, while chronic administration produced 1.7- to 3.5-fold increases, remaining below levels necessary to produce adverse cardiovascular effects.
Authors
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Does not support clinical use changes; leaves open translation of fenfluramine's 5-HT effects to human cardiovascular outcomes.
Rothman et al. (2008) studied this question. Fenfluramine vs. Vehicle was evaluated on Plasma 5-HT. Acute fenfluramine increased plasma 5-HT up to 24-fold, while chronic administration produced 1.7- to 3.5-fold increases, remaining below levels necessary to produce adverse cardiovascular effects.
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