Key result
In patients with incident atrial fibrillation, low albumin was a significant predictor of sudden cardiac death (HR 1.23 per SD decrease), distinct from non-sudden cardiovascular death.
Population
2,321 adults with incident atrial fibrillation from the community-based Atherosclerosis Risk in Communities…
Design
Cohort
Follow-up
median 3.3 years from the time of incident AF
Authors
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Low albumin associated with SCD (not other CV death) in incident AF; hypothesis-generating and requires prospective validation before risk-stratification use.
Cohort (n=2,321)
Yes
Hazard Ratio: 1.23 (95% CI 1.02–1.48)
p-value: p=0.03
In community-dwelling individuals with incident atrial fibrillation, clinical factors including coronary heart disease, diabetes, LVH, increased BMI, higher heart rate, and low albumin independently predict the risk of sudden cardiac death.
Koene et al. (2017) conducted a cohort in Incident atrial fibrillation (n=2,321). Low albumin (per SD decrease) vs. Higher albumin levels was evaluated on Sudden cardiac death (HR 1.23, 95% CI 1.02-1.48, p=0.03). In patients with incident atrial fibrillation, low albumin was a significant predictor of sudden cardiac death (HR 1.23 per SD decrease), distinct from non-sudden cardiovascular death.
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