October 1, 1995Arteriosclerosis Thrombosis and Vascular Biology
T 2 -Weighted Contrast for NMR Characterization of Human Atherosclerosis
Why the study?
Does T1- and T2-weighted 1H NMR imaging adequately characterize the components of human atheromatous arteries?
Population
Microdissected components of diseased and normal human arteries with atherosclerotic lesions of graded…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
T2 contrast at high field supports ex vivo atheroma component mapping; leaves open in vivo human translation.
Structured PICO
Does T1- and T2-weighted 1H NMR imaging adequately characterize the components of human atheromatous arteries?
P
Population
Microdissected components of diseased and normal human arteries with atherosclerotic lesions of graded severity
I
Intervention
1H NMR spectroscopy and imaging (T1-weighted and T2-weighted sequences) at 1.5, 4.7, and 9.4 T
O
Outcome
Water relaxation constants (T1 and T2), relative content of mobile lipid, and contrast-to-noise ratio (CNR)surrogate
The combination of T1- and T2-weighted NMR sequences permits in vitro identification of atheroma components, providing a basis for potential in vivo microscopy of human atherosclerosis.
Cite This Study
Toussaint et al. (1995) studied this question.