Key result
Targeting lymphatic system dysregulation emerges as a potential therapeutic strategy for volume management in HF.
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Highlights the underappreciated role of the lymphatic system in volume homeostasis and its dysregulation in heart failure, suggesting it as a potential therapeutic target.
The lymphatic system is an integral part of the circulatory system and plays an important role in the volume homeostasis of the human body. The complex anatomy and physiology paired with a lack of simple diagnostic tools to study the lymphatic system have led to an underappreciation of the contribution of the lymphatic system to acute and chronic heart failure (HF). Herein, we discuss the physiological role of the lymphatic system in volume management and the evidence demonstrating the dysregulation of the lymphatic system in HF. Further, we discuss the opportunity to target the lymphatic system in the management of HF and different potential approaches to accessing the lymphatic system.
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Fudim et al. (2021) conducted a review in Heart Failure. The lymphatic system plays an important role in volume homeostasis and is dysregulated in heart failure, presenting a potential therapeutic target for volume management.
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