Human Diarrheal Disease Caused by Enterotoxigenic Escherichia Coli

HUMANS 336 CHARACTERIZATION OF E. COLI ENTEROTOXINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 Heat-Stable and Heat-Labile Enterotoxins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 Cultural Conditions for Production of Enterotoxin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 Animal and Cell Models for Detection of E. coli Enterotoxins . . . . . . . . . . . . . . . . . . . 339 Physiological Effects 0/ E. coli Enterotoxins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 342 Cellular and Biochemical Effects of E. coli Enterotoxins. . . . . . . . . . . . . . . . . . . . . . . . 342 Purification of E. coli Enterotoxins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 344 Genetic Control of Enterotoxin Production in E. coli... . . . . . . . . . . . . . . . . . . . . . . . . 344 Relationship of E. coli Serotypes to Enterotoxin Production . .. .. . . . . . . . . . . . . . . . . 345 Importance 0/ K Antigens to Pathogenicity of Animal Enterotoxigenic E. coli.. . . . . . 346 Immunological Studies 0/ E. coli Enterotoxins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 347 Epidemiologic Studies 0/ Enterotoxigenic E. coli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 348 Enterotoxin Assays in Parenteral Isolates of E. coli ... . . . . . . . . . . . . . . . . . . . . . . . . . 349 Pathogenesis and Clinical Spectrum of Disease Produced by Enterotoxigenic E. coli. 350 Laboratory Diagnostic Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 350 Possibilities for Immunological Control of Disease Due to Enterotoxigenic E. coli .. . 350 Areas for Research. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351