Induction of cardiac arrest using a lithium battery followed by ALS protocol resulted in successful resuscitation in 7 of 15 pigs, contingent on coronary perfusion pressure and PETCO2 levels.
The use of an ordinary lithium battery to induce cardiac arrest in Landrace/Large White pigs provides a simple and valuable experimental model for resuscitation research.
Sudden cardiac death (SCD) is a field of continuous research. In order to answer various questions regarding SCD, several animal models have been developed. The aim of the present study is to describe our experimental model of inducing cardiac arrest in Landrace/Large White pigs, and then resuscitated according to the International Guidelines on resuscitation. Fifteen Landrace/Large White pigs were anaesthetized and intubated while spontaneously breathing. The left and right jugular veins, as well as the femoral and the carotid arteries, were surgically prepared. Induction of cardiac arrest was achieved by using an ordinary rechargeable lithium battery, through a pacemaker wire inserted into the right ventricle. The typical Advanced Life Support (ALS) protocol was followed, and in case of restoration of spontaneous circulation, the animals were further evaluated for 30 min. Seven animals were successfully resuscitated using this protocol, whereas eight failed resuscitation efforts. Successful resuscitation was contingent on the restoration of the levels of coronary perfusion pressure and PETCO(2) during chest compressions. Among the different ways of inducing cardiac arrest, the ordinary lithium battery is a simple, safe and valuable technique. Landrace/Large White pigs' baseline haemodynamics closely resemble human haemodynamics, making the breed a favourable model for resuscitation.
Xanthos et al. (Sun,) conducted a other in Cardiac arrest (n=15). Induction of cardiac arrest using a lithium battery and ALS resuscitation was evaluated on Successful resuscitation. Induction of cardiac arrest using a lithium battery followed by ALS protocol resulted in successful resuscitation in 7 of 15 pigs, contingent on coronary perfusion pressure and PETCO2 levels.