A Two-Directional Approach for the Solid-Phase Synthesis of Trisaccharide Libraries

Without protecting groups, polymer-bound thioglycosyl sugars can undergo two successive glycosylation reactions, once as a donor and once as an acceptor, to give trisaccharides such as 1. Trisaccharide libraries prepared by this strategy have a known sugar residue at the reducing or nonreducing ends. •=polymer resin+amide linker.