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May 14, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

A critical review on In Vivo and Ex Vivo models for the investigation of Helicobacter pylori infection

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Authors

SPSavita PatilSYSongmin YuRJRenitta Jobby

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Overview

This review examines infection models for Helicobacter pylori to improve drug development and vaccine research.

Key Points

  • The central aim is to evaluate existing in vivo and ex vivo models for studying Helicobacter pylori infection and to identify gaps in current knowledge.
  • Review of various animal and non-animal models used to study Helicobacter pylori infection.
  • Discussion of the molecular mechanisms of infection and associated pathophysiological responses.
  • Analysis of ongoing challenges in drug development and vaccine research.
  • H. pylori prevalence is around 45% in adults, contributing to gastritis and gastric cancer.
  • Current eradication strategies depend on traditional antibiotics, facing challenges due to antimicrobial resistance.
  • Development of novel models is critical for advancing therapeutic options and understanding infection dynamics.

Cite This Study

Patil et al. (2025) studied this question.

synapsesocial.com/papers/6a21f6701b095894fc4ea174https://doi.org/10.3389/fcimb.2025.1516237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Research advances of the establishment and characterization of Helicobacter pylori infection animal models2025
  2. 2Helicobacter pylori vaccines: from bench to bedside—progress, challenges, and future directions2026
  3. 3Conventional and Novel Approaches to Establishing Mouse Models of Gastric Cancer in the Past, Present, and Potential Post-H. Pylori Infection Era2026
  4. 4Molecular Mechanisms of Helicobacter pylori Infection: A Review2025
  5. 5Novel therapeutic regimens against Helicobacter pylori: an updated systematic review2024 · 42 citations