Why the study?
Does the presence and size of an angioplasty catheter influence measured mean pressure gradients across human coronary artery stenoses?
Does the presence and size of an angioplasty catheter influence measured mean pressure gradients across human coronary artery stenoses?
The presence of an angioplasty catheter during translesional pressure measurements causes significant flow blockage, which can lead to inaccurate hemodynamic assessments.
May artifactually elevate measured coronary pressure gradients; leaves open validation of catheter-size corrections in human physiology studies.
Quantitative methods to measure the hemodynamic consequences of various endovascular interventions including balloon angioplasty are limited. Catheters measuring translesional pressure drops during balloon angioplasty procedures can cause flow blockage and thus inaccurate estimates of pre- and post-intervention flow rates. The purpose of this investigation was to examine the influence of the presence and size of an angioplasty catheter on measured mean pressure gradients across human coronary artery stenoses. Analytical flow modeling and in vitro experimental evidence, coupled with angiographic data on the dimensions and shape of stenotic vessel segments before and after angioplasty, indicated significant flow blockage effects with the catheter present.
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Back et al. (1996) studied this question.
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