Key result
Calcium entry blockers reduced premature ventricular contractions (from 21 to 5.7/h) and left ventricular mass, whereas hydrochlorothiazide had no effect.
Why the study?
Do calcium entry blockers reduce cardiac dysrhythmias and left ventricular mass compared to hydrochlorothiazide in hypertensive patients?
Observational (n=23)
Do calcium entry blockers reduce cardiac dysrhythmias and left ventricular mass compared to hydrochlorothiazide in hypertensive patients?
Absolute Event Rate: 5.7% vs 16%
Calcium entry blockers, unlike thiazide diuretics, reduce left ventricular mass and the prevalence and severity of ventricular dysrhythmias in hypertensive patients.
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May favor calcium entry blockers over thiazides for hypertensive patients with ectopy; observational data leave open need for RCTs.
Franz H. Messerli (1989) conducted an observational in Hypertension (n=23). Calcium entry blockers vs. Hydrochlorothiazide was evaluated on Premature ventricular contractions (events/h). Calcium entry blockers reduced premature ventricular contractions (from 21 to 5.7/h) and left ventricular mass, whereas hydrochlorothiazide had no effect.
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