The CKM syndrome score provided a broader assessment of comorbidities at earlier stages than ASCVD risk classification, with 22% of advanced CKM patients having a low ASCVD risk.
Cross-Sectional (n=500)
Does the CKM syndrome score provide a broader assessment of comorbidities compared to ASCVD risk stratification in primary care patients with cardiometabolic risk factors?
The CKM syndrome score identifies broader cardiometabolic risks at earlier stages compared to traditional ASCVD risk scores, as evidenced by 22% of advanced CKM patients having low ASCVD risk.
Background/Objectives: Cardiovascular disease is the leading cause of death in Mexico; this is due to the high prevalence of chronic non-communicable diseases (NCDs), including obesity, type 2 diabetes mellitus (T2DM), systemic arterial hypertension (SAH), cardiovascular disease, chronic kidney disease (CKD), and dyslipidemia. Primary care physicians require a classification tool that enables them to gain a broader understanding of their patients’ risks, thereby allowing them to make more informed clinical decisions. This study compared risk stratification for atherosclerotic cardiovascular disease (ASCVD) and Cardiovascular–Kidney–Metabolic (CKM) syndrome in a primary care setting in Mexico. Methods: An observational, descriptive, cross-sectional study analyzed 500 patients with T2DM, SAH, dyslipidemia, and/or CKD. Two ordinal logistic regression models were developed using a Chi-square test, Kruskal–Wallis test, and tetrachoric, polychoric, polyserial, and Pearson correlations. Results: Associations were found between ASCVD risk and factors like sex, age, and T2DM; for CKM syndrome, the associations were with age, T2DM, and dyslipidemia. Interestingly, 22% of advanced CKM patients had a low ASCVD risk. Alcohol consumption showed a strong positive relationship (42%) with CKM stages, while there was a negative relationship (33%) with the glomerular filtration rate. Conclusions: The ASCVD risk classification effectively identifies cardiac conditions, but the CKM syndrome score provides a broader assessment of comorbidities at earlier stages. Key factors like age, hypertension, T2DM, and smoking are crucial for cardiovascular risk but less so for CKM syndrome, highlighting the need for a broader stratification of risk.
Vázquez-Martínez et al. (Thu,) conducted a cross-sectional in Type 2 diabetes mellitus, systemic arterial hypertension, dyslipidemia, and/or chronic kidney disease (n=500). Cardiovascular-Kidney-Metabolic (CKM) syndrome score vs. Atherosclerotic cardiovascular disease (ASCVD) risk classification was evaluated on Risk stratification for ASCVD and CKM syndrome. The CKM syndrome score provided a broader assessment of comorbidities at earlier stages than ASCVD risk classification, with 22% of advanced CKM patients having a low ASCVD risk.