Why the study?
How do changes in vascular properties affect the impedance spectra of the systemic circulation in a computational model?
How do changes in vascular properties affect the impedance spectra of the systemic circulation in a computational model?
A computational fluid-circuit analogic model successfully predicts input impedance spectra and demonstrates how changes in vascular properties like arterial stiffness affect these hemodynamic parameters.
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Model findings on stiffness and impedance warrant in vivo validation; leaves open clinical translation or practice change.
A viscoelastic four‐tube arteries—micro‐vessels—veins model has been built using transmission line network. Hemodynamic data from literature are used in the fluid‐circuit analogic model. The predicted input impedance spectra agree reasonably well with the published measurements. Parametric analysis shows that the changes in the vascular properties in different portions of the body cause fluctuations of the maxima or minima of the impedance spectrum. In general, the changes of vascular properties in the lower body affect the first minimum, and the changes in the upper body influence the second minimum. Decreasing capacitances (i.e., increasing arterial stiffness due to aging), reducing the lumen area, or decreasing the length of blood vessels result in an increase of the impedance modulus, and the shift of the first minimum to a higher frequency, which agree well with experiments. The changes of peripheral resistances of all terminations affect the magnitude of impedance modulus maxima only. The current model uses simple physiological data directly; it can be used to simulate the effect of pharmacologic manipulation on the impedace spectra of the patients.
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Chen et al. (1996) studied this question.
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