Why the study?
Does concomitant use of clopidogrel and proton pump inhibitors increase the risk of recurrent myocardial infarction in patients with a prior acute MI?
Does concomitant use of clopidogrel and proton pump inhibitors increase the risk of recurrent myocardial infarction in patients with a prior acute MI?
The apparent increased risk of recurrent MI with concomitant clopidogrel and PPI use is likely driven by confounding by indication rather than a true adverse drug interaction.
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Increased recurrent MI risk with current (vs no) PPI likely reflects confounding; supports no true clopidogrel-PPI interaction and leaves open need for RCTs.
Valkhoff et al. (2010) studied this question.
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