Key result
Over a 15-year follow-up, Senning patients showed a significant decrease in apical peak systolic strain of the subaortic right ventricle (-17 ± 7% vs -12 ± 4%; p=0.025).
Why the study?
Right ventricular dysfunction is a major concern in Senning patients, but long-term follow-up data was lacking.
How does regional right and left ventricular function change over a 15-year follow-up period in patients after the Senning operation?
Observational (n=10)
How does regional right and left ventricular function change over a 15-year follow-up period in patients after the Senning operation?
Absolute Event Rate: -12% vs -17%
p-value: p=0.025
In patients post-Senning operation, subaortic RV function remains largely stable over 15 years except for apical decline, though it remains significantly lower than matched controls.
Apical RV strain decline may warrant serial monitoring in Senning survivors; leaves open optimal surveillance for subaortic RV dysfunction.
Introduction Despite right ventricular (RV) dysfunction being a major concern in Senning patients, long-term follow-up data is lacking. This study aimed (1) at evaluating regional (base-mid-apex) RV and left ventricular (LV) function using Colour-Doppler myocardial imaging over a 15-year follow-up period and (2) at comparing results with matched controls.Methods For the longitudinal analysis (2004–2019), we compared systolic and diastolic function in 10 Senning patients. For the cross-sectional analysis, we compared the subaortic RV (sRV) of Senning patients with the RV and LV of matched controls and the subpulmonary LV (spLV) of Senning patients with the LV of matched controls.Results The longitudinal analysis of sRV function showed a significant decrease in apical peak systolic strain (−17 ± 7% vs −12 ± 4%; p = 0.025) and apical peak systolic strain rate (−1.1 ± 0.3s−1 vs −0.8 ± 0.4s−1; p = 0.012). spLV function showed a significant decrease in peak systolic velocity (mid; p = 0.013 and apex; p = 0.011) and peak systolic strain rate (mid; p = 0.048). The cross-sectional analysis revealed significant lower values for basal, mid and apical peak systolic velocity, peak systolic strain rate, peak systolic strain of the sRV of Senning patients when compared to both LV and RV of matched controls (all p < 0.05).Conclusion Our study showed that systolic and diastolic sRV function did not change over a 15-year follow-up period, except in the apical region. There was a decline in spLV systolic function, which may be of clinical value. On the other hand, when compared to age- and gender-matched controls, the sRV of Senning patients exhibits significantly decreased measurements of longitudinal systolic function.
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Moyá et al. (2020) conducted an observational in Senning operation (n=10). Senning operation vs. Baseline (longitudinal) and matched controls (cross-sectional) was evaluated on Apical peak systolic strain of the subaortic right ventricle (p=0.025). Over a 15-year follow-up, Senning patients showed a significant decrease in apical peak systolic strain of the subaortic right ventricle (-17 ± 7% vs -12 ± 4%; p=0.025).
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