Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Dilated cardiomyopathy secondary to frequent atrial premature contractions (n=1). Intervention: Radiofrequency catheter ablation. Primary outcome: Left ventricular ejection fraction and dimensions.

Faris Khan; Mansoor Ahmad; Sumera Kanwal; Jason Payne; Shane Tsai; Daniel R. Anderson

doi:10.1016/j.jaccas.2021.04.004

June 2, 2021JACC Case ReportsOpen Access

Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy

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Graphical abstract published by JACC Case Reports — Graphical abstract · Published by JACC Case Reports · CC BY

Why the study?

Unlike ventricular premature contractions, there is a paucity of data demonstrating an association between arrhythmia-induced cardiomyopathy and frequent atrial premature contractions.

Does APC ablation reverse left ventricular dysfunction in patients with dilated cardiomyopathy secondary to frequent APCs?

Key Points

This research investigates the relationship between atrial premature contractions and dilated cardiomyopathy, focusing on their reversible nature.
Reviewed cases of patients with frequent atrial premature contractions presenting with dilated cardiomyopathy.
Assessed left ventricular function before and after APC ablation procedures.
Successful ablation of atrial premature contractions led to significant improvement in left ventricular function.
Most patients recovered normal left ventricular ejection fraction post-procedure.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

Does APC ablation reverse left ventricular dysfunction in patients with dilated cardiomyopathy secondary to frequent APCs?

P

Population

A 28-year-old man with a long-standing history of frequent atrial premature contractions leading to left ventricular dysfunction, followed for 3 months post-ablation.

I

Intervention

APC ablation

O

Outcome

Reversal of left ventricular dysfunctionsurrogate

Limitations

Single case report
Pathophysiology of APC-induced cardiomyopathy is not well understood

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Implication

Frequent atrial premature contractions can cause a reversible form of dilated cardiomyopathy that improves with successful ablation.

Abstract

Arrhythmia-induced cardiomyopathy secondary to frequent ventricular premature contractions is a well-studied phenomenon; however, there is a paucity of data showing a similar association with frequent atrial premature contractions (APCs). Early recognition and successful APC ablation can reverse left ventricular dysfunction in these patients. (Level of Difficulty: Beginner.)

Discussion

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Cite This Study

Khan et al. (2021) conducted a case report in Dilated cardiomyopathy secondary to frequent atrial premature contractions (n=1). Radiofrequency catheter ablation was evaluated on Left ventricular ejection fraction and dimensions.

synapsesocial.com/papers/6a2205a75c15637a5057fc31 https://doi.org/10.1016/j.jaccas.2021.04.004

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Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy

Figures

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Relatively Benign yet a Reversible Cause of Dilated Cardiomyopathy

Figures

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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