Key result
Atherosclerosis impaired endothelium-dependent vasodilation, with methacholine reducing calf vascular resistance by -64% in controls compared to 6% in patients (p<0.01).
Why the study?
Does peripheral atherosclerosis impair the vasodilator responsiveness of peripheral resistance and conduit vessels to intra-arterial infusions of vasoactive agents?
Case-Control (n=17)
Does peripheral atherosclerosis impair the vasodilator responsiveness of peripheral resistance and conduit vessels to intra-arterial infusions of vasoactive agents?
Absolute Event Rate: 6% vs -64%
p-value: p=<0.01
Peripheral atherosclerosis is associated with impaired endothelium-dependent vasodilation in resistance vessels and blunted responses to both endothelium-dependent and -independent vasodilators in conduit vessels.
No takes yet. Share an insight, caveat, or question.
Impaired vasodilation in atherosclerosis supports endothelial assessment; hypothesis-generating and should not yet change practice.
Liao et al. (1991) conducted a case-control in Peripheral atherosclerotic disease (n=17). Atherosclerosis vs. Control subjects was evaluated on Change in calf vascular resistance in response to methacholine (p=<0.01). Atherosclerosis impaired endothelium-dependent vasodilation, with methacholine reducing calf vascular resistance by -64% in controls compared to 6% in patients (p<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: