Key result
Distinct immune cells regulate zebrafish heart regeneration and offer potential targets for cardiac repair.
Why the study?
Understanding proregenerative immune-mediated mechanisms in zebrafish may identify therapeutic targets to enhance cardiac repair in myocardial infarction and heart failure.
Understanding the temporal coordination and regulatory signaling pathways of immune cells in zebrafish heart regeneration may identify novel therapeutic targets for cardiac repair in myocardial infarction and heart failure.
No role yet for immune modulation in human MI or HF; leaves open translation of zebrafish findings to clinical targets.
Zebrafish possess a remarkable capacity to regenerate cardiac tissues after injury, offering a powerful model to dissect the cellular and molecular mechanisms driving heart regeneration. Immune cells play distinct and context-dependent roles during regeneration, from debris clearance and inflammation resolution to modulation of cell proliferation and fibrosis. Here, we review the distinct contributions of neutrophils, macrophages, and lymphoid cells during zebrafish heart regeneration, with a focus on their temporal coordination and regulatory signaling pathways. Understanding proregenerative immune-mediated mechanisms may identify therapeutic targets to enhance cardiac repair in disease contexts, such as myocardial infarction and heart failure.
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Zhang et al. (2025) conducted a review in Heart regeneration. Immune cell regulation was evaluated. Immune cells, including neutrophils, macrophages, and lymphoid cells, play distinct and context-dependent roles during zebrafish heart regeneration, offering potential targets for cardiac repair.
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