Skeletal muscle force and actomyosin ATPase activity reduced by nitric oxide donor

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Population

Single permeabilized muscle fibers from the rabbit psoas muscle

Design

Preclinical

Authors

Discussion

Alerts to possible off-target NO donor effects on muscle force; leaves open translation from animal fibers to human cardiac or clinical settings.

Population

Single permeabilized muscle fibers from the rabbit psoas muscle

Intervention

Sodium nitroprusside (SNP; 100 microM to 10 mM) or N-ethylmaleimide (NEM; 5-250 microM)

Outcome

Isometric force and actomyosin ATPase activitysurrogate

The NO donor sodium nitroprusside inhibits contractile function in skeletal muscle fibers through reversible oxidation of contractile protein thiols.

Perkins et al. (1997) studied this question.

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Alerts to possible off-target NO donor effects on muscle force; leaves open translation from animal fibers to human cardiac or clinical settings.