August 1, 1987AJP Cell Physiology

Mechanical properties of skinned single fibers of identified types from rat diaphragm

Q: What is the clinical evidence from this study?

Study design: Other. Intervention: Fast fibers (Type II) vs. Slow fibers. Primary outcome: Maximum isometric tension, maximum velocity of shortening, and tension-pCa relationships.

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Key result

Physiologically fast fibers from rat diaphragm had larger cross-sectional areas, produced more tension per area, and were less sensitive to calcium than physiologically slow fibers.

Authors

TEThomas J. EddingerMarquette University RMRichard L. MossUniversity of Vermont

Discussion

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Implication

Rat diaphragm data should not yet inform clinical decisions; extends basic fiber-type physiology but requires disease-model validation.

PICO

Exposure / Comparator

Fast fibers (Type II) vs Slow fibers

Primary Outcome

Maximum isometric tension, maximum velocity of shortening, and tension-pCa relationships

Cite This Study

Eddinger et al. (1987) studied this question. Fast fibers (Type II) vs. Slow fibers was evaluated on Maximum isometric tension, maximum velocity of shortening, and tension-pCa relationships. Physiologically fast fibers from rat diaphragm had larger cross-sectional areas, produced more tension per area, and were less sensitive to calcium than physiologically slow fibers.

synapsesocial.com/papers/6a220e2ac7675eb28596f6f7 https://doi.org/10.1152/ajpcell.1987.253.2.c210

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Mechanical properties of skinned single fibers of identified types from rat diaphragm

Discussion

Member takes

Implication

PICO

Cite This Study

Mechanical properties of skinned single fibers of identified types from rat diaphragm

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Also Consider