Key result
Matrix metalloproteinase inhibition with batimastat prevented the normalization of wall stress during vascular remodeling after balloon angioplasty in atherosclerotic pigs.
Why the study?
Does matrix metalloproteinase inhibition with batimastat modulate shear stress and wall stress regulation of vascular remodeling after balloon angioplasty in atherosclerotic pigs?
Population
12 atherosclerotic Yucatan pigs undergoing balloon angioplasty (PTA) in external iliac arteries
Comparison
Matrix metalloproteinase inhibition with… vs Control group without MMPI (6 pigs, 10 vessels)
Design
Preclinical
Follow-up
6 weeks
Authors
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Disrupts wall stress normalization in porcine angioplasty model; leaves open MMP role in human vascular remodeling.
Does matrix metalloproteinase inhibition with batimastat modulate shear stress and wall stress regulation of vascular remodeling after balloon angioplasty in atherosclerotic pigs?
Vascular remodeling after balloon angioplasty is controlled by both shear stress and wall stress, and matrix metalloproteinase inhibition disrupts the wall stress control system.
Wentzel et al. (2001) studied Restenosis after balloon angioplasty (n=12). Matrix metalloproteinase inhibition (batimastat) vs. Control was evaluated on Vascular remodeling (shear stress and wall stress normalization). Matrix metalloproteinase inhibition with batimastat prevented the normalization of wall stress during vascular remodeling after balloon angioplasty in atherosclerotic pigs.
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