Higher HDL-C levels were associated with a lower risk of MACEs in hypertensive men (HR 0.78 per 10 mg/dl increase; 95% CI 0.70-0.88; p<0.0001), but not in women.
Observational (n=9,323)
Are higher HDL-C levels associated with a reduced risk of MACEs in male and female hypertensive patients?
Higher HDL-C levels are associated with a lower incidence of major adverse cardiovascular events in male hypertensive patients, but not in females.
Hazard Ratio: 0.78 (95% CI 0.7–0.88)
p-value: p=<.0001
BACKGROUND: The relationship between high-density lipoprotein cholesterol (HDL-C) levels and major adverse cardiovascular events (MACEs) in hypertensive patients of different sexes is unclear. HYPOTHESIS: Sex differences in the relationship between HDL-C levels and the risk of MACEs among hypertensive patients. METHODS: We performed a post-hoc analysis of data obtained from the Systolic Blood Pressure Intervention Trial (SPRINT) and explored sex-based differences in the relationship between HDL-C levels and MACEs among hypertensive patients using Cox proportional hazards regression. RESULTS: A total of 9323 hypertensive patients (6016 64.53% men and 3307 35.47% women) were assessed using SPRINT data. MACEs occurred in 395 (6.57%) men and 166 (5.02%) women after a mean follow-up of 3.26 years. When HDL-C levels were used as a continuous covariate, each 10 mg/dl increase in HDL-C levels decreased the risk of MACEs in men (hazard ratio HR, 0.78; 95% confidence interval CI, 0.70-0.88; p < .0001). However, HDL-C levels were not associated with MACEs in female hypertensive patients (HR, 1.02; 95% CI, 0.89-1.16; p = .7869). Compared with those in the first quartile, MACEs in the fourth quartile had the lowest risk among male patients (HR, 0.58; 95% CI, 0.41-0.82; p = .0023). Female patients in the fourth quartile of HDL-C levels had an HR of 1.09 for MACEs (95% CI, 0.62-1.93; p = .7678). HDL-C levels were not associated with the risk of MACEs among females. CONCLUSION: Among elderly hypertensive patients, higher HDL-C levels were associated with a lower MACE incidence in men but not in women. Unique identifier: NCT01206062.
Wang et al. (Tue,) conducted a observational in Hypertension (n=9,323). High-density lipoprotein cholesterol (HDL-C) levels vs. Lower HDL-C levels was evaluated on Major adverse cardiovascular events (MACEs) (HR 0.78, 95% CI 0.70-0.88, p=<.0001). Higher HDL-C levels were associated with a lower risk of MACEs in hypertensive men (HR 0.78 per 10 mg/dl increase; 95% CI 0.70-0.88; p<0.0001), but not in women.