Key result
Supplemental and dietary calcium consumed with a high-fat meal did not significantly affect postprandial blood pressure or microvascular function in obese women.
Why the study?
Does supplemental or dietary calcium alter blood pressure and microvascular function postprandially in obese women challenged with a high-fat meal?
RCT (n=16)
Randomized to one of three possible sequences
No
Does supplemental or dietary calcium alter blood pressure and microvascular function postprandially in obese women challenged with a high-fat meal?
In obese women, neither supplemental nor dietary calcium significantly alters the acute effects of a high-fat meal on blood pressure and microvascular function.
Calcium offers no postprandial BP or microvascular benefit with high-fat meals in obese women; challenges hypotheses of acute vascular effects.
Recent studies suggest that supplemental Ca (SC) increases the risk of cardiovascular events, whereas dietary Ca (DC) decreases the risk of cardiovascular events. Although frequently consumed with meals, it remains unclear whether Ca can mitigate or aggravate the deleterious effects of a high-fat meal on cardiovascular risk factors. This study aimed to evaluate the effects of SC or DC on blood pressure (BP) and microvascular function (MVF) in the postprandial period in obese women challenged with a high-fat meal. In this cross-over controlled trial, sixteen obese women aged 20-50 years were randomly assigned to receive three test meals (2908 kJ (695 kcal); 48 % fat): high DC (HDCM; 547 mg DC), high SC (HSCM; 500 mg SC-calcium carbonate) and low Ca (LCM; 42 mg DC). BP was continuously evaluated from 15 min before to 120 min after meals by digital photoplethysmography. Before and 120 min after meals, participants underwent evaluation of serum Ca and microvascular flow after postocclusive reactive hyperaemia (PORH) by laser speckle contrast imaging. Ionised serum Ca rose significantly only after HSCM. Systolic BP increased after the three meals, whereas diastolic BP increased after LCM and HDCM. Hyperaemia peak, hyperaemia amplitude and AUC evaluated after PORH decreased with LCM. After HDCM, there was a reduction in hyperaemia peak and hyperaemia amplitude, whereas HSCM decreased only hyperaemia peak. However, comparative analyses of the effects of three test meals on serum Ca, BP and MVF revealed no significant meal×time interaction. This study suggests that in obese women SC and DC do not interfere with the effects of a high-fat meal on BP and MVF.
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Ferreira et al. (2016) conducted an RCT in Obesity (n=16). Supplemental calcium vs Dietary calcium vs. Low calcium meal (42 mg Ca) was evaluated on Postprandial blood pressure and microvascular function (meal × time interaction) (p=not significant). Supplemental and dietary calcium consumed with a high-fat meal did not significantly affect postprandial blood pressure or microvascular function in obese women.
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