Key result
Moderate to severe carotid artery stenosis was associated with higher mean hs-CRP compared to controls (p≤0.001), but hs-CRP did not differentiate symptomatic from asymptomatic patients.
Why the study?
Do inflammatory markers such as hs-CRP differentiate between symptomatic and asymptomatic patients with moderate to severe carotid artery stenosis?
Observational (n=70)
Do inflammatory markers such as hs-CRP differentiate between symptomatic and asymptomatic patients with moderate to severe carotid artery stenosis?
While hs-CRP is elevated in patients with moderate to severe carotid artery stenosis, it does not reliably differentiate between symptomatic and asymptomatic presentations.
Answers are grounded in this paper and cite their sources.
hs-CRP does not differentiate symptomatic from asymptomatic carotid stenosis; leaves open its prognostic value pending prospective validation.
Inflammatory markers may help establish the diagnosis of carotid atherosclerotic disease and predict the progression and outcomes. We evaluated inflammatory markers in symptomatic and asymptomatic patients with moderate to severe carotid artery stenosis, including high-sensitivity C-reactive protein (hs-CRP), leukocyte count, leukocyte subgroups and erythrocyte sedimentation rate. There were 32 symptomatic and 16 asymptomatic patients (age ≥50 years) with moderate to severe carotid stenosis detected by color Doppler ultrasonography, and 22 individuals without atherosclerotic findings on Doppler ultrasonography. The mean hs-CRP was significantly greater in the symptomatic (p = 0.001) and asymptomatic (p < 0.001) patients than control subjects; there was no significant difference between symptomatic and asymptomatic patients in mean hs-CRP values. Compared with control subjects, asymptomatic patients had greater mean leukocyte count (p = 0.016). Compared with control subjects, symptomatic patients had greater mean neutrophil count (p = 0.012), monocyte count (p = 0.021) and erythrocyte sedimentation rate (p = 0.001). The hs-CRP was associated with moderate to severe carotid artery stenosis, but it did not differentiate symptomatic and asymptomatic patients.
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Güven et al. (2012) conducted an observational in Carotid artery stenosis (n=70). Moderate to severe carotid artery stenosis vs. Individuals without atherosclerotic findings was evaluated on Mean high-sensitivity C-reactive protein (hs-CRP) (p=<0.001). Moderate to severe carotid artery stenosis was associated with higher mean hs-CRP compared to controls (p≤0.001), but hs-CRP did not differentiate symptomatic from asymptomatic patients.
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