Why the study?
Do high-sensitivity C-reactive protein levels and carotid plaque characteristics correlate with the severity of coronary artery disease in elderly patients?
Do high-sensitivity C-reactive protein levels and carotid plaque characteristics correlate with the severity of coronary artery disease in elderly patients?
Elevated serum hs-CRP levels and increased carotid intima-media thickness correlate closely with the severity of coronary artery disease in elderly patients, suggesting their utility as noninvasive predictors of CAD severity.
hs-CRP and carotid IMT elevations may aid noninvasive CAD severity assessment in elderly patients; leaves open added predictive value beyond standard factors.
The aim of this study was to explore the correlation of high-sensitivity C-reactive protein (hs-CRP) and carotid plaques with the severity of coronary artery disease (CAD). A total of 140 patients with angina who underwent coronary angiography were selected and divided into a single-vessel disease group (n=11), double-vessel disease group (n=18), multi-vessel disease group (n=71) and control group (n=40). Color Doppler ultrasound was applied to measure the intima-media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation, and to record the location and number of carotid plaques. The serum hs-CRP level was also determined. Compared with the control and single-vessel disease groups, the multi-vessel disease group showed significantly higher IMT of the CCA (P<0.05). The serum hs-CRP level was highest in the multi-vessel disease group (P<0.01). The hs-CRP level and carotid plaque characteristics were found to correlate closely with the severity of CAD. Therefore, they may be used to improve the prediction of CAD severity in elderly patients.
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Liang et al. (2015) studied this question.
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