Simultaneous optical mapping and transmural microelectrode recordings in rabbit hearts quantified the probing-depth constant for near-infrared dyes at ~2.1 mm, clarifying the influence of depth and lateral scattering on optical action potentials.
Rabbit optical mapping signals warrant cautious interpretation; leaves open validation in larger models before clinical use.
Because of the optical features of heart tissue, optical and electrical action potentials are only moderately associated, especially when near-infrared dyes are used in optical mapping (OM) studies.
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Mačianskienė et al. (2015) studied this question.
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