Why the study?
Does nicardipine improve exercise capacity and delay ischemia in patients with chronic stable effort angina pectoris?
Population
n=19 patients with chronic, stable effort angina pectoris
Comparison
Nicardipine administered three times daily vs Placebo
Design
RCT, Randomized in an extended Latin-Square study design, Double-blinded…
Authors
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Supports nicardipine for symptom relief in stable angina; confirms anti-ischemic efficacy versus placebo in RCT.
Does nicardipine improve exercise capacity and delay ischemia in patients with chronic stable effort angina pectoris?
Nicardipine at 90 mg/day significantly improves exercise capacity and delays the onset of angina and ischemia in patients with chronic stable angina, though gradual dose titration is needed to minimize adverse effects.
Thomas et al. (1990) studied this question.
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