Key result
A new flexible spline-based analytical model of the left ventricle was developed and verified against DT-MRI data, enabling physiological simulations such as scroll wave dynamics.
The proposed spline-based analytical model provides a flexible, non-symmetrical representation of the left ventricle that can be constructed from routine sonography and used for physiological simulations.
May facilitate arrhythmia modeling research; leaves open clinical validation of sonography-derived LV models.
Computer simulation of normal and diseased human heart activity requires a 3D anatomical model of the myocardium, including myofibers. For clinical applications, such a model has to be constructed based on routine methods of cardiac visualization, such as sonography. Symmetrical models are shown to be too rigid, so an analytical non-symmetrical model with enough flexibility is necessary. Based on previously-made anatomical models of the left ventricle, we propose a new, much more flexible spline-based analytical model. The model is fully described and verified against DT-MRI data. We show a way to construct it on the basis of sonography data. To use this model in further physiological simulations, we propose a numerical method to utilize finite differences in solving the reaction-diffusion problem together with an example of scroll wave dynamics simulation.
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Sergei F. Pravdin (2016) studied Cardiac left ventricle anatomy and morphology. Spline-based analytical model of the left ventricle vs. Symmetrical models was evaluated on Model verification against DT-MRI data and physiological simulations. A new flexible spline-based analytical model of the left ventricle was developed and verified against DT-MRI data, enabling physiological simulations such as scroll wave dynamics.
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