Population
Three-dimensional electro-mechanical model of cardiac tissue
Design
Preclinical
Key result
In a cardiac electro-mechanical model, stretch-activated currents prolonged action potential duration by 10-15 ms, and adding a convective term reduced repolarization dispersion by 7%.
Authors
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May influence repolarization in models; hypothesis-generating for mechano-electric effects on arrhythmias, needing in vivo validation.
Mechanical feedbacks in cardiac tissue, specifically stretch-activated currents and convective terms, significantly alter action potential duration and repolarization dispersion, potentially influencing arrhythmogenic mechanisms.
Franzone et al. (2015) studied Cardiac electro-mechanical modeling. Stretch-activated currents (ISAC) and convective term vs. Model without mechanical feedbacks was evaluated on Action potential duration (APD) and dispersion of repolarization. In a cardiac electro-mechanical model, stretch-activated currents prolonged action potential duration by 10-15 ms, and adding a convective term reduced repolarization dispersion by 7%.