Key result
Mathematical modelling demonstrated that abrupt shortening and stretch of cardiac preparations can cause extra action potentials, acting as potential arrhythmia sources.
This mathematical modeling study provides theoretical insights into how mechanical deformations like stretch and shortening can trigger arrhythmias and contribute to the Anrep phenomenon.
Hypothesis-generating for mechano-electric arrhythmia triggers; leaves open experimental validation before clinical relevance.
We earlier developed the mathematical model of electrical and mechanical activity in myocardium, which takes into account both direct coupling and feedback between excitation and contraction. In this paper, in the framework of the model we found conditions under which both the abrupt shortening and stretch of cardiac preparation can cause extra action potentials and hence anomalous deformations can be arrhythmia sources. In the framework of the model, we establish possible mechanisms underlying the Anrep phenomenon that reflects a relationship between myocardium contraction and vascular resistance in the intact heart.
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Solovyova et al. (2004) studied Arrhythmia. Mathematical modelling was evaluated. Mathematical modelling demonstrated that abrupt shortening and stretch of cardiac preparations can cause extra action potentials, acting as potential arrhythmia sources.
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