What is the clinical evidence from this study?

Population: Cardiac Arrhythmias. Intervention: Mechanical stretch vs. Normal hearts. Primary outcome: Stretch-induced depolarizations, action potentials, and arrhythmias.

What does this research mean for the field?

Activation of mechano-sensitive conductances by mechanical stretch can trigger depolarizations, ectopic beats, and reentrant arrhythmias at physiologically plausible levels, matching the paradoxical systolic stretch observed in ischemic myocardium. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1998Journal of Theoretical BiologyOpen Access

Model Studies of the Role of Mechano-sensitive Currents in the Generation of Cardiac Arrhythmias

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Key result

Mechanical stretch via mechano-sensitive conductances evokes depolarizations and arrhythmias in cardiac models, mirroring ischemic hearts.

Structured PICO

Population

Single cardiac cell models, one- and two-dimensional cardiac network models; patients with infarcts or recent ischemic events and normal hearts

Exposure

Incorporation of linear, instantaneously activating mechano-sensitive conductances to simulate mechanical stretch

Comparator

Models without stretch; normal hearts without paradoxical deformation

Outcome

Action potential characteristics (amplitude, maximum diastolic potential, peak upstroke velocity, conduction velocity), stretch-induced depolarizations, and arrhythmiassurrogate

Computational models demonstrate that mechano-electrical feedback from paradoxical systolic stretch, as observed by MRI in ischemic hearts, can generate cardiac arrhythmias.

Discussion

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Implication

Supports mechano-electrical feedback in ischemia models; leaves open clinical relevance in humans.

Cite This Study

Rice et al. (1998) studied Cardiac Arrhythmias. Mechanical stretch vs. Normal hearts was evaluated on Stretch-induced depolarizations, action potentials, and arrhythmias. Mechanical stretch activating mechano-sensitive conductances evoked depolarizations and arrhythmias in cardiac models, corresponding to paradoxical systolic stretch observed in ischemic human hearts.

synapsesocial.com/papers/6aa8915519414f39eb5cc226 https://doi.org/10.1006/jtbi.1997.0538

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Model Studies of the Role of Mechano-sensitive Currents in the Generation of Cardiac Arrhythmias

Structured PICO

Discussion

Implication

Cite This Study

Model Studies of the Role of Mechano-sensitive Currents in the Generation of Cardiac Arrhythmias

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider