Toxicity of thallium.

metabolism was studied in vitro.Rapid ingestion of food was accompanied by an increase in the incorporation of isotope-labelled pyruvate into glyceride-glycerol and fatty acids, as well as by increased activity of glycerol-3-phosphate dehydrogenase.These results suggest enhanced lipogenesis during a gorging regimen.Though the evidence is by no means conclusive, this study provides a further indication that taking infrequent meals may be associated with a ten- dency to obesity and hyperlipidaemia.The modern Western tendency is to eat a large proportion of the day's calories at one evening meal.Though infrequent feeding is probably not pathogenic in itself, it may become so when combined with a high-calorie intake and a low-energy expenditure.Whether or not the high incidence of atherosclerosis which afflicts man, and which has been correlated with serum lipid levels, can be influenced by alteration of the pattern of food intake is at present unknown, but this question deserves further study.