Key result
Neonates with enterovirus infections had a significantly higher risk of death compared to infected persons aged ≥1 month (11.5% vs 2.5%; OR 5.1; 95% CI 3.3-7.8).
Why the study?
What are the common enterovirus serotypes and their association with fatal outcomes in neonates compared to older individuals?
Population
26,737 enterovirus detections reported to the National Enterovirus Surveillance System during 1983-2003…
Design
Cohort
Authors
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Neonates with enterovirus warrant close monitoring; this cohort study leaves open serotype-specific fatality risks.
Observational (n=26,737)
Yes
What are the common enterovirus serotypes and their association with fatal outcomes in neonates compared to older individuals?
Odds Ratio: 5.1 (95% CI 3.3–7.8)
Absolute Event Rate: 11.5% vs 2.5%
Neonatal enterovirus infections, particularly with coxsackievirus B4, are associated with a significantly higher risk of death compared to infections in older individuals.
Khetsuriani et al. (2006) conducted an observational in Enterovirus infections (n=26,737). Neonatal age vs. Age ≥1 month was evaluated on Fatal outcome (OR 5.1, 95% CI 3.3-7.8). Neonates with enterovirus infections had a significantly higher risk of death compared to infected persons aged ≥1 month (11.5% vs 2.5%; OR 5.1; 95% CI 3.3-7.8).
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