Key points are not available for this paper at this time.
(Second of Two Parts)Rejection and HistocompatibilityAlthough the possibility of rejection is always present, nonimmunologic causes of early hepatic dysfunction must be ruled out systematically. The differential diagnosis can include suboptimal revascularization; defects in biliary reconstruction that cause obstruction or bile fistula; opportunistic infection with cytomegalovirus,119 , 120 herpes simplex viruses,120 Epstein–Barr virus, or adenovirus121; infection by various bacterial or fungal pathogens122; toxicity caused by hyperalimentation or sepsis123; and hepatotoxicity of the drugs used to prevent rejection.45, 124 Later graft dysfunction can be caused by a recurrence of the disease that destroyed the native liver, infection of the transplant . . .
Starzl et al. (Thu,) studied this question.