Key result
Rapid atrial pacing at 400/min reduced the Bmax of dihydropyridine receptors from 157 fmol/mg in controls to 94 fmol/mg at 42 days (P<0.01), without altering beta-adrenergic receptors.
Why the study?
Does rapid atrial pacing alter the number and binding affinity of dihydropyridine and beta-adrenergic receptors in a canine model?
Does rapid atrial pacing alter the number and binding affinity of dihydropyridine and beta-adrenergic receptors in a canine model?
Absolute Event Rate: 94% vs 157%
p-value: p=<0.01
Rapid atrial activation downregulates the number of L-type Ca2+ channels, contributing to the electrical remodeling seen in atrial fibrillation.
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Suggests L-type Ca channel downregulation in AF remodeling; leaves open translation to human therapies.
Rania Gaspo (1999) studied Tachycardia-induced atrial fibrillation (n=52). Rapid atrial pacing vs. Sham-operated controls was evaluated on Bmax of dihydropyridine receptors (p=<0.01). Rapid atrial pacing at 400/min reduced the Bmax of dihydropyridine receptors from 157 fmol/mg in controls to 94 fmol/mg at 42 days (P<0.01), without altering beta-adrenergic receptors.
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