Semiquantitative wash-in rate on PWI/DCE significantly differentiated responders from partial/non-responders in undifferentiated pleomorphic sarcoma (P=0.0078).
Observational
Does perfusion-weighted imaging with dynamic contrast enhancement (PWI/DCE) predict pathology-assessed treatment response in patients with undifferentiated pleomorphic sarcoma?
PWI/DCE MRI features, specifically TIC-type II curve, low wash-in rate, and capsular enhancement, can accurately predict pathology-assessed treatment response in undifferentiated pleomorphic sarcoma.
p-value: p=0.0078
), and 60% expressed a TIC-type V (P = 0. 06). Semiquantitative wash-in rate (WiR) was able to separate R vs. PR/NR (P = 0. 0078). The WiR radiomics displayed significant differences in the firstₒrder₁0 percentile (P = 0. 0178) comparing R vs. PR/NR at PRT. The PWI/DCE TIC-type II curve, low WiR, and "Capsular" enhancement represent PRT patterns typically observed in successfully treated UPS and demonstrate potential for UPS treatment response assessment.
Valenzuela et al. (Tue,) conducted a observational in Undifferentiated pleomorphic sarcoma (UPS). Perfusion-weighted imaging with dynamic contrast enhancement (PWI/DCE) was evaluated on Treatment response (Responder vs. Partial/Non-Responder) (p=0.0078). Semiquantitative wash-in rate on PWI/DCE significantly differentiated responders from partial/non-responders in undifferentiated pleomorphic sarcoma (P=0.0078).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: