Why the study?
Do increased depressive symptoms increase all-cause mortality in middle-aged subjects with elevated cardiovascular risk across different BMI categories?
Population
2,509 middle-aged subjects with elevated cardiovascular risk from a Finnish primary care setting, without…
Comparison
Increased depressive symptoms vs No increased depressive symptoms (BDI score <10)
Design
Cohort
Follow-up
14 years
Key result
Increased depressive symptoms were associated with a significantly higher risk of all-cause mortality (HR 3.26) specifically among subjects with normal weight (BMI < 25.0 kg/m2), but not among those with overweight or obesity.
Authors
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Increased depressive symptoms are associated with a significantly higher risk of all-cause mortality specifically among normal-weight individuals with elevated cardiovascular risk, but not among those with overweight or obesity.
Cohort (n=2,509)
Yes
Do increased depressive symptoms increase all-cause mortality in middle-aged subjects with elevated cardiovascular risk across different BMI categories?
Increased depressive symptoms are associated with a significantly higher risk of all-cause mortality specifically among normal-weight individuals with elevated cardiovascular risk, but not among those with overweight or obesity.
Hazard Ratio: 3.26 (95% CI 1.83–5.82)
Absolute Event Rate: 21.5% vs 6%
Rantanen et al. (2023) conducted a cohort in Elevated cardiovascular risk (n=2,509). Increased depressive symptoms (BDI ≥ 10) vs. No increased depressive symptoms (BDI < 10) was evaluated on All-cause mortality in subjects with BMI < 25.0 kg/m2 (HR 3.26, 95% CI 1.83 to 5.82). Increased depressive symptoms were associated with a significantly higher risk of all-cause mortality (HR 3.26) specifically among subjects with normal weight (BMI < 25.0 kg/m2), but not among those with overweight or obesity.