Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2004Psychosomatic Medicine

Depressive Symptoms and Mortality Risk in a National Sample: Confounding Effects of Health Status

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Are depressive symptoms independently associated with increased all-cause mortality in noninstitutionalized adults?

Population

3,617 noninstitutionalized adults, age ≥25 years, from the Americans' Changing Lives Study

Comparison

Higher depressive symptoms vs Lower depressive symptoms

Design

Cohort

Follow-up

7.5 years

Authors

SESusan A. Everson‐RosePreventive CardiologyJHJames S. HouseFlorida State UniversityRMRichard P. MeroUniversity of Michigan

Discussion

Loading...

Member takes

Implication

Depressive symptoms lose independent mortality link after physical health adjustment; supports confounding by baseline function in observational cohorts.

Key Points

  • This research investigates the connection between depressive symptoms and all-cause mortality, considering the influence of health status.
  • Participants included 3617 noninstitutionalized adults aged 25 and older from the Americans' Changing Lives Study.
  • Depressive symptoms were assessed using the Center for Epidemiological Studies Depression Scale (CES-D).
  • Cox proportional hazards models were used to estimate the relative risk of mortality based on baseline CES-D scores.
  • Over 7.5 years, 542 deaths occurred, with each 1-unit increase in CES-D linked to a 21% increased mortality risk (HR=1.21, 95% CI=1.08-1.36, p=0.001).
  • After adjusting for education, income, BMI, smoking, and alcohol, the risk reduced to 13% (HR=1.13, 95% CI=0.99-1.28, p=0.06).
  • Controlling for chronic health conditions eliminated the mortality association, indicating no link in those with good health or no impairments.

Structured PICO

Are depressive symptoms independently associated with increased all-cause mortality in noninstitutionalized adults?

P
Population
3,617 noninstitutionalized adults, age ≥25 years, from the Americans' Changing Lives Study (nationally representative sample)
I
Intervention
Higher depressive symptoms (measured by the 11-item Center for Epidemiological Studies Depression Scale [CES-D])
C
Comparator
Lower depressive symptoms
O
Outcome
All-cause mortality at 7.5 years follow-uphard clinical

Depressive symptoms are not independently associated with mortality risk in the general population when adequately adjusting for baseline physical health status.

Cite This Study

Everson‐Rose et al. (2004) studied this question.

synapsesocial.com/papers/6a221bcd9e220ae9ef494f89https://doi.org/10.1097/01.psy.0000145903.75432.1f
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depressed Affect, Hopelessness, and the Risk of Ischemic Heart Disease in a Cohort of U.S. Adults1993 · 783 citations
  2. 2Depression and Cardiac Mortality2001 · 929 citations
  3. 3Rates and Predictors of Mortality in an Aging, Rural, Community-Based Cohort2002 · 171 citations
  4. 4Depressive symptoms and risk of functional decline and death in patients with heart failure2001 · 529 citations
  5. 5Depressive Symptomatology and Hypertension-Associated Morbidity and Mortality in Older Adults1995 · 228 citations