Key result
In patients with major depressive disorder, elevated monocyte count was significantly associated with an increased risk of coronary heart disease (B=7.521; 95% CI 3.409-11.633; p<0.001).
Why the study?
Patients with major depressive disorder face an increased risk of coronary heart disease, but the underlying mechanisms remain unclear.
Are inflammatory biomarkers associated with increased coronary heart disease risk in patients with major depressive disorder?
Population
454 patients with acute MDD and 458 age- and gender-matched controls
Comparison
Patients with acute MDD vs matched controls
Design
Cross-sectional study
Authors
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May inform CHD risk stratification in MDD; leaves open causal role and need for prospective validation.
Cross-Sectional (n=912)
Are inflammatory biomarkers associated with increased coronary heart disease risk in patients with major depressive disorder?
Effect estimate: B=7.521 (95% CI 3.409-11.633)
p-value: p=<0.001
Elevated monocyte count is significantly associated with higher predicted coronary heart disease risk in patients with major depressive disorder, suggesting a role for systemic inflammation.
Zhou et al. (2020) conducted a cross-sectional in Major depressive disorder (n=912). Major depressive disorder and elevated monocyte count vs. Healthy controls was evaluated on Coronary heart disease risk assessed using the Framingham risk score (B=7.521, 95% CI 3.409-11.633, p=<0.001). In patients with major depressive disorder, elevated monocyte count was significantly associated with an increased risk of coronary heart disease (B=7.521; 95% CI 3.409-11.633; p<0.001).
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