Key result
Elevated LncRNA AF085935 was identified as the most significant risk factor for the occurrence of hepatocellular carcinoma in chronic HCV patients (OR 18.824).
Why the study?
Chronic HCV infection frequently leads to cirrhosis and HCC, but the molecular mechanisms driving HCV-induced HCC and new early diagnostic markers remained to be clarified.
Are serum levels of IGF, FOXO, and LncRNA AF085935 associated with the development of HCC in patients with chronic HCV infection?
Case-Control (n=180)
No
Are serum levels of IGF, FOXO, and LncRNA AF085935 associated with the development of HCC in patients with chronic HCV infection?
Odds Ratio: 18.824 (95% CI 8.196–43.234)
p-value: p=<0.001
HCV may induce HCC through the upregulation of IGF, which subsequently induces LncRNA AF085935 and FOXO, suggesting these could serve as diagnostic markers.
May aid HCV-HCC risk stratification; leaves open prospective validation before clinical use.
HCV is the most commonly occurring hepatic infection worldwide. Chronic HCV infection usually complicated with cirrhosis and even HCC with significant morbidity and mortality. The aim of this study to clarify the molecular mechanism by which HCV can induce HCC and identify a new diagnostic marker for early detection of HCC. Methods: 180 participating subject were divided in to three groups. Group 1: 60 healthy individuals (controls). Group 2: 60 HCV infected patients. Group 3: 60 HCV patients developed HCC. Serum IGF, FOXO and LncRNA AF085935 were evaluated. Results: Serum IGF was significantly elevated in HCV and HCC patients, while FOXO and LncRNA AF085935 were significantly up regulated in HCC. IGF significantly correlated with and LncRNA AF085935. Conclusion: HCV can induce IGF with subsequent induction of LncRNA AF085935 and FOXO.
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Mostafa et al. (2021) conducted a case-control in Hepatitis C virus (HCV) and Hepatocellular carcinoma (HCC) (n=180). LncRNA AF085935, FOXO, and IGF levels vs. Healthy controls and uncomplicated HCV patients was evaluated on Prediction of occurrence of HCC in HCV patients (OR 18.824, 95% CI 8.196-43.234, p=<0.001). Elevated LncRNA AF085935 was identified as the most significant risk factor for the occurrence of hepatocellular carcinoma in chronic HCV patients (OR 18.824).
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