During developmentally scheduled vascular regression, resident macrophages are an obligatory participant in a signaling switch mediated by angiopoietin 2 that favors cell death over survival.
Resident macrophages actively participate in developmentally scheduled vascular regression via an angiopoietin 2-mediated signaling switch that promotes endothelial cell death.
Macrophages have a critical function in the recognition and engulfment of dead cells. In some settings, macrophages also actively signal programmed cell death. Here we show that during developmentally scheduled vascular regression, resident macrophages are an obligatory participant in a signaling switch that favors death over survival. This switch occurs when the signaling ligand angiopoietin 2 has the dual effect of suppressing survival signaling in vascular endothelial cells (VECs) and stimulating Wnt ligand production by macrophages. In response to the Wnt ligand, VECs enter the cell cycle and in the absence of survival signals, die from G1 phase of the cell cycle. We propose that this mechanism represents an adaptation to ensure that the macrophage and its disposal capability are on hand when cell death occurs.
Rao et al. (Mon,) conducted a other in Developmentally scheduled vascular regression. Angiopoietin 2 and resident macrophages was evaluated on Programmed cell death during vascular regression. During developmentally scheduled vascular regression, resident macrophages are an obligatory participant in a signaling switch mediated by angiopoietin 2 that favors cell death over survival.