Key result
The homozygous L genotype of the human insulin gene was significantly more frequent in diabetic hypertriglyceridaemic patients (39%) compared to non-diabetic hypertriglyceridaemic patients (0%, P<0.001).
Why the study?
Is the 5' flanking polymorphism of the human insulin gene associated with diabetic hypertriglyceridaemia?
Population
126 individuals, comprising a control population and a hypertriglyceridaemic group, which included diabetic…
Comparison
5' flanking polymorphism of the human insulin gene vs Control population and non-diabetic…
Design
Case-control
Authors
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May indicate genetic link to diabetic hypertriglyceridaemia; leaves open confirmation in larger cohorts.
Case-Control (n=126)
Is the 5' flanking polymorphism of the human insulin gene associated with diabetic hypertriglyceridaemia?
Absolute Event Rate: 39% vs 0%
p-value: p=<0.001
Jowett et al. (1984) conducted a case-control in Diabetic hypertriglyceridaemia (n=126). 5' flanking polymorphism of the human insulin gene (homozygous L genotype) vs. Control population and non-diabetic hypertriglyceridaemic patients was evaluated on Homozygous L genotype frequency in diabetic vs non-diabetic hypertriglyceridaemic patients (p=<0.001). The homozygous L genotype of the human insulin gene was significantly more frequent in diabetic hypertriglyceridaemic patients (39%) compared to non-diabetic hypertriglyceridaemic patients (0%, P<0.001).
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